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Tamara Koval, who worked at the company from 2012 to 2014 and helped coordinate clinical trials for the device, questioned the quality of some of the researchers and sites contracted to carry out those experiments

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Experiments have also shown that nicotine reduces blood flow in cardiac blood vessels (coronary arteries) by causing them to constrict

The following compounds, used as tobacco additives, may have an effect on the central nervous system: acetophenone, isoamyl alcohol, valerian oil, theobromine, and valerenic acid (Lington and Bevan 1994, Moreno 1978,, Oliva et al