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Approved for clinical use by the US FDA, PLGA is a popular choice for biomaterials for many reasons, including its biocompatibility and degradation properties, which can be tailored based on its molecular weight and, if used in combination with another polymer, its copolymer ratio (Patel et al., 2021)

To elucidate the potential mechanisms underlying this protection phenotype, we adopted a chemical genetic approach by conducting a focused compound screen that included compounds targeting ferroptosis-related pathways

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