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Hepatotoxicity induced by APAP is mainly caused by the production of N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive intermediate formed predominantly via the cytochrome P450 2E1

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Your immune system responds, and your histamine levels skyrocket, and then you have explosive diarrhea

Cell lines were routinely tested for mycoplasma contamination

In an orthotopic pancreatic cancer model, this metabolic co-inhibition approach resulted in robust tumor suppression with minimal systemic toxicity (Fig