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References: Wang C, Crapo LM (1997) The epidemiology of thyroid disease and implications for screening

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*Correspondence: Richard Eugene Frye, Arkansas Childrens Hospital Research Institute, Slot 512-41B, 13 Childrens Way, Little Rock, AR 72202, USA e-mail: [email protected] This article was submitted to Child and Neurodevelopmental Psychiatry, a section of the journal Frontiers in Pediatrics

For CMS, the currently identified potential pathogenic mechanisms only show a negative correlation with CMS, lacking direct evidence of causality

it is heavily regulated by the brain and spinal cord through what are known as descending inhibitory pain pathways