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Notes that alternative pathways such as polyamine biosynthesis could compensate for raised SAM, that partial rather than total inhibition may be preferable to avoid compensatory mechanisms from an imbalanced SAM/SAH ratio, and that the consequences of sustained NNMT inhibition on systemic epigenetics remain unclear

Drugs.com says that some side effects associated with the injections include nausea, vomiting, indigestion, and mild diarrhea

Breast tenderness or swelling Mild bloating or abdominal cramping Headache or fatigue Water retention (feeling puffy or swollen) Serious (but rare) side effects: Ovarian Hyperstimulation Syndrome (OHSS): severe abdominal pain, rapid weight gain, nausea, or breathing difficulty Increased chance of multiple pregnancies (twins or more) Blood clots (pain, redness, swelling in limbs) Ovarian torsion (twisting of the ovary, resulting in severe pain) Allergic reactions: rash, itching, swelling, or trouble breathing In boys: early puberty signs, such as a deeper voice and increased body hair

It also improves fluid buildup in the abdomen and around the lungs

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