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Its important to acknowledge that, like any field of scientific inquiry, the current research has inherent limitations

Multiple meta-analyses and pooled analyses of the published literature have found that low-protein diets and very-low-protein diets supplemented with nitrogen-free derivatives of essential amino acids (eg, compounds called keto-analogues or keto acids) have a range of benefits in slowing disease progression

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The quantification of lactate is possible because the MM components are included in the basis set and because LCModel expects to find lactate