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Dietary (poly) phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases

In this review, we discussed the interaction between gut microbiota and cholesterol metabolism, especially the cholesterol-lowering effect of statins mediated by gut microbiota, via AMPK-PPAR-SREBP1C/2, FXR and PXR-related, and LPS-TLR4-Myd88 pathways, which may help to explain the individual differences in statins efficacy

Dichloroacetate and cancer: new home for an orphan drug

8 Further studies also include anti-atherosclerotic and lipid-lowering effects, 9,42 fibrinolytic activity and effects on coagulation, 6,16 and pharmacokinetics 60 and toxicology 61 in humans