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Comments: Commenters were supportive of the continued APC assignment to APC 5724 (Level 4 Diagnostic Tests and Related Services)

Drug resistance remains one of the leading bottlenecks contributing to unsatisfactory therapeutic outcomes and eventual treatment failure during clinical cancer chemotherapy, and abundant preclinical evidence has confirmed that abnormally elevated NNMT expression is closely correlated with acquired drug resistance across various solid and hematologic malignancies

HR 0.70 [95% CI 0.530.93], P = .0075) in patients with multiple myeloma with the addition of selinexor

The correct interpretation of any result depends on the biological model, assay sensitivity, positive and negative controls, exposure period, analytical method, and the reproducibility of the dataset