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The first cardiovascular study of NNMT enzyme inhibition in a heart failure with preserved ejection fraction (HFpEF) mouse model demonstrated that treatment markedly reduced 1-MNA (by 77.1%), 2PY (by 66.2%), and 4PY (by 71.1%) in cardiac tissue, while improving cardiac function, enhancing global longitudinal strain, reversing peak longitudinal strain rate, and significantly reducing left ventricular hypertrophy and fibrosis

Intramuscular injections might sound a little frightening, but they're routine

(Liu et al., 2015) extended these findings, revealing a positive association between serum MNAM levels and obesity

Khouri JF1

Competing interests The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported