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Pellagra can be prevented by about 11 mg NE/day, but 12 mg to 16 mg NE/day has been found to normalize the urinary excretion of niacin metabolites (breakdown products) in healthy young adults

That's an unusually efficient tool for metabolic investigation

It has been examined in laboratory and clinical research models related to metabolic regulation , energy balance , and feeding behavior

When consuming 100 g of fat daily, a healthy individual should excrete 7 g or less per day of fat in their stool

but the lack of dietary supplements, the use of nitrous oxide during general anesthesia, and long-term use of the antiepileptic drug phenytoin have been reported as risk factors for acute neurological deterioration [3, 11]