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The Working Group also noted that the study did not provide historical control data.] In another micronucleus assay in mice, aspartame was administered as a single oral dose of 500, 1000, or 2000 mg/kg bw by gavage to male CD-1 mice

10.21037/atm-21-378 47 LiP.ZhangR.WangM.ChenY.ChenZ.KeX.et al (2022a)

The S-chiral ester of NPAA (S-NPAA) was two-fold more effective than the R-chiral ester (R-NPAA) in depleting GSH, increasing oxidative stress, inducing apoptosis, and decreasing cell viability in tumorigenic prostate LNCaP cells but had little effect on non-tumorigenic RWPE-1 cells

Coadministration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets

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