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Prognosis challenges persist: high tumor burden, poor-risk features (e.g., 3 IMDC factors), and resistance to traditional chemotherapy, which shows minimal efficacy in ccRCC

Faced with these alternatives I grasped the larger hope. Wishing to fit myself for active-service conditions I overcame the ordinary weaknesses of the flesh

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The PRISMA flow diagram of an updated systematic review on the relationship between smoking and chronic obstructive pulmonary disease conducted on PubMed to update historical review from previous cycles of the Global Burden of Disease Study