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It suppresses Erk1/2 and Akt phosphorylation generated by PDGF-BB

thaliana (Su et al., 2011)

GLS is highly expressed in various malignancies and has been widely studied as a target for cancer therapy

A similar reasoning can be used for autophagy modulation with lithium-based compounds, which was of no benefit in mouse models and had limited impact in human trials [88]