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Excessive mtROS and disrupted mitochondrial dynamics amplify inflammation and impair host defense

Following T cell activation, CD154 is expressed on the surface of the cell, allowing binding to B cells through CD40

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To verify if the increased expression of GCLC , GSS , and GSR had a functional impact on the activity of the GSH pathway, we measured total intracellular glutathione levels and ratio of reduced (GSH) to oxidized (GSSG) glutathione after 24 hours of BDG exposure ( Figure 4D )

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