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doi: 10.1038/s41598-018-29826-4 Shen, Huaizong, Li, Zhangqiang, Jiang, Yan, Pan, Xiaojing, Wu, Jianping, Cristofori-Armstrong, Ben, Smith, Jennifer J., Chin, Yanni K

Y., Fay, A

Upon absorption, curcumin undergoes first and second-pass metabolisms in the liver and intestine, mainly through reduction (phase I) and conjugation (phase II)