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NNMTi-treatment offers a promising therapeutic approach to address this unmet need 8,9,13

4.1 Limitations and implications for practice This meta-analysis has several limitations that should be considered when interpreting the findings

Rapid weight loss without adequate protein leads to muscle loss, which slows metabolism and creates the "skinny fat" outcome where the scale looks good but body composition tells a disappointing story

This might mean combining several approaches, being patient with yourself, and communicating openly with all the practitioners involved in your care

Semaglutide which has a FDA approval is the GLP-1 receptor agonist, another anti-obesity medication currently available for long-term use for weight loss