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doi: 10.1016/j.freeradbiomed.2010.04.006 129 Martn-MontaezEPaviaJValverdeNBoraldiFLaraEOliverBet al

Regulation of NLRP3 inflammasome by CD38 through cADPR-mediated Ca(2+) release in vascular smooth muscle cells in diabetic mice

Furthermore, in vitro studies demonstrated that melatonin can enhance the effect of 5-fluorouracil in colon cancer cells via the activation of caspase-9 and caspase-3 in the mitochondrial apoptotic pathway [160], increasing oxidative stress, downregulating genes and proteins related to apoptosis resistance [161], and inhibiting NF-B/iNOS and PI3K/AKT signaling pathways [162]