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[The Working Group noted that the limitations of the study included the use of a single concentration level, the lack of information on aberrant types and mitotic index, and the evaluation of cytotoxicity (by MTT assay), rather than cell replication.] However, in another study, a statistically significant increase in the frequency of chromosomal aberrations was also reported at all three tested concentrations (500, 1000, and 2000 g/mL) in human lymphocytes treated with aspartame for 24 or 48 hours (Renczoullari et al., 2004)

The table summarises the types of nanoparticles their active reagents, applications in terms of targeting delivery in BBB, clinical status, and the disease in which it plays the role

Free radicals attack the collagen and elastic fibers of the skin that affect the skin hydration and stimulate wrinkle formation

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