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This may result in an excess of reactive oxygen species that could help to explain accelerated ageing in children with Down syndrome

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doi: 10.1016/j.scitotenv.2023.168627 239 XiaY.QiY.YuanY.WangG.CuiJ.ChenY.et al

7 Blocking the export of intracellular GSH does not impair the ability of GSH to rescue in cystine-free conditions

Within the pathological milieu of uremia-associated CKD, the intestinal microbiome undergoes profound compositional dysregulation, manifesting as precipitous depletion of beneficial microbial taxaparticularly short-chain fatty acid (SCFA)-producing genera including Faecalibacterium prausnitzii , Roseburia, Bifidobacterium, and Lactobacillusconcomitant with the aberrant proliferation of opportunistic pathogenic species such as Escherichia coli , Shigella, and Enterococcus (Lyu et al., 2023