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Most reports describe first changes at weeks 4 to 6, with peak effect at 8 to 12 weeks

Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin

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Hence, the rationale for a UL that refers to all stereoisomers of -tocopherol is based on the fact that any form of -tocopherol (natural or synthetic) can be absorbed and thus be potentially harmful