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Effect of non-steroidal anti-inflammatory drugs on glutathione levels in various organs of rat

Mevalonate pathway The mevalonate pathway occurs in the cytoplasm, where Acetoacetyl-CoA thiolase (AACT) produces acetoacetyl-CoA by condensation of two units of acetyl-coA, and then 3-hydroxy-3-methylglutaryl CoA synthase (HMGS) condensates acetoacetyl-CoA and acetyl-CoA to form 3-hydroxy-3-methylglutaryl CoA (HMG-CoA), which is then catalyzed by hydroxymethylglutaryl-CoA reductase (HMGR) to generate mevalonic acid (MVA)

For cardiac function measurements, M-mode echocardiography was used, and left ventricular internal diameter at end-diastole and left ventricular internal diameter at end-systole was measured to calculate the value of ejection fraction (EF)

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