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World Anti-Doping Agency (WADA) : Prohibited in sports due to unproven effects and potential unfair advantages ([4])

J Physiol Pharmacol Off J Pol Physiol Soc

Direct, large-scale, double-blind Western randomized controlled trials are lacking

PLoS ONE 8:e81640

The research rationale established by NNMT-knockdown studies in diet-induced-obese mice is that inhibiting NNMT preserves intracellular NAD+ and SAM levels, which in adipocyte (fat-cell) models has been shown to suppress de novo lipogenesis