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Within healthy individuals, the concentration of copper ranges from 50 to 120 mg, a modest amount compared to other primary trace elements such as iron and zinc

CHAC1 supplies the matrix cysteine pool in the absence of extracellular cystine To determine if CHAC1 has a discernable influence on the pools of mitochondrial cysteine and GSH in the potential support of Fe-S cluster synthesis, we endeavored to monitor the availability of these metabolites in response to cystine starvation (Fig

Targeting predictions (TargetP [45, 46], LOCALIZER [47] and PredAlgo [48], Additional file 1 Table S1) as well as the presence or absence of N-terminal sequence extensions suggest a high variability in subcellular targeting

Carfilzomib (Kyprolis ) is a 2 nd generation, irreversible inhibitor of the 20S proteasomal subunit