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Histamine suppresses gene expression and synthesis of tumor necrosis factor alpha via histamine H2 receptors

20 The release of hormones such as norepinephrine, dopamine, serotonin and -aminobutyric acid by the central nervous system influences brain chemicals that suppress eating and increase metabolic rate (such as pro-opiomelanocortin and cocaine-amphetamine-regulated transcript) as well as those that suppress eating and decrease metabolic rate (such as neuropeptide Y, Agouti-related peptide, melanin-concentrating hormone, and orexin)