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However, this conclusion does not apply to all cell types as levels of UPR effectors known to be induced (BIP, XBP1s, IRE1) or activated (pEIF2) upon ER stress did not change upon STARD7 deficiency in ER + breast cancer-derived T47D and MCF7 cells nor in IECs from 100 days old Apc +/Min /Stard7 IEC mice (Fig

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If the problem hasnt resolved after a maximum of two injections in one site, consideration should be given to other forms of treatment