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[ [P489 Table] Factors affecting engraftment in APSCT] P490 Pre-transplant mutational burden predicts for post-transplant outcomes in myelodysplastic syndrome and acute myeloid leukemia Katherine Prendergast 1 , Adam Seegmiller 2 , Heidi Chen 3 , Wichai Chinratanalab 4 , Brian Engelhardt 4 , Stacey Goodman 4 , Carole Hunt 5 , Adetola Kassim 4 , Bipin Savani 4 , Michael Savona 4 , Salyka Sengsayadeth 4 , Madan Jagasia 4 , Michael Byrne 4 1 2 3 4 4 4 5 4 4 4 4 4 4 1 Vanderbilt University School of Medicine, Nashville, TN, United States

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IGF1R derived PI3K/AKT signaling maintains growth in a subset of human T-cell acute lymphoblastic leukemias