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The antioxidant defense system includes: superoxide dismutase, catalase and other enzymatic antioxidants as well as non-enzymatic antioxidants such as albumin, uric acid and glutathione

As a newly discovered mechanism of iron-induced cell death, ferroptosis is considered a significant candidate for the major death process of dopaminergic neuronal cells due to its close relationship with iron and lipid peroxidation (Dixon et al., 2012

For example, Korichneva et al demonstrated that zinc was released from protein kinase C (PKC) during activation by ROS and was thus involved in the myocardial redox signaling network 12,29

It addresses a bottleneck