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This translational gap motivates an engineering solution: polysaccharide-based nanomedicines that exploit the inflammatory microenvironment (pH, ROS, bacterial glycosidases, receptor overexpression) to achieve spatiotemporally controlled delivery and thereby amplify the very mechanisms delineated above

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Sukenik S, Buskila D, Neumann L, Kleiner-Baumgarten A, Zimlichman S, Horowitz J: Sulphur bath and mud pack treatment for rheumatoid arthritis at the Dead Sea area

Because it is so central to our internal health, many people seek to supplement it, especially as natural production tends to decline with age or increased environmental stress