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Antidepressant efficacy is associated with substantial inhibition of MAO activity , although the precise degree of inhibition required for clinical response has not been definitively established

Godlewska et al

2E, Fig

This balanced composition enables precise evaluation of combined molecular activity under standardized experimental conditions, supporting structured analytical protocols

Affected individuals exhibit substantially lower levels of muscle oxygen saturation compared to healthy norms, with reductions of up to 20% from an expected average of about 75%.14,15,16 The exact mechanisms behind this decrease in oxygen saturation levels remain unclear, leaving researchers to speculate whether the primary cause is reduced mitochondrial energy production capacity or an increased demand for energy within muscle fibers.17 Given the mitochondrias essential role in energy generation through aerobic metabolism, exploring mitochondrial dysfunction could illuminate the reduced physical capabilities observed in fibromyalgia patients.18 This comprehensive narrative review is meticulously crafted with the objective of unveiling and articulating the critical role of muscle oxygen saturation within the fibromyalgia framework