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Dose-response and pharmacokinetics Research to characterize absorption, distribution, metabolism, and excretion in reproductive organs, as well as safe dose ranges and optimal delivery routes for focused targeting of gonadal tissue without systemic exposure

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have created mouse models like the aging FAD4T, AD-specific APP/PS1, and mature microglial Dox-BV2, showing that H3K18la enhances NFB signaling by upregulating the expression of Rela (p65) and NFB1 (p50) [76]