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Authors information YO, HA, SY and MM were the researchers in the same laboratory and cooperatively carried out the study

and Udenfriend, S

Excessive iron accumulation in cells can generate ROS through the Fenton reaction, leading to lipid peroxidation ( GPX4 is a critical regulator in preventing ferroptosis, as it inhibits ferroptosis by catalyzing the reduction of lipid peroxides ( Figure 1 )

Adjibade M, Andreeva VA, Lemogne C, Touvier M, Shivappa N, Hbert JR, Wirth MD, Hercberg S, Galan P, Julia C, Assmann KE, Kesse-Guyot E

Thus, an increase in NRF2 activity, reflected by induction of NRF2 target genes, likely represent an important mechanism mediating the protection seen in GCLM KO mice