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FIGURE 5 In the case of DPSC-treated mdx mice, the top activated upstream regulators included methamphetamine in an inhibitory state targeting molecules such as 4-hydroxy-3-methoxyphenylacetic acid, 5-hydroxytryptamine, creatinine, GABA, and glutathione as predicted, and upstream regulators BHMT, UCP1, NOS1, and GNRH1 in the activated state, targeting molecules such as creatinine, GABA, L-arginine, L-glutamic acid, oleic acid, phosphorylcholine, and glycero-3-phosphocholine

This strategy effectively circumvents the delivery bottlenecks of native GDNF and has become a focus of current translational research [123]

[PubMed: 11682622] 10

Additionally, PEPR1 kinase reduced BAK1 phosphorylation in vitro

C., Sandmark, J., Schneider, G