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The nucleoside reverse transcriptase inhibitor (NRTI) antiretroviral drug class for instance, is known to cause depletion of mitochondrial DNA via inhibition of the mitochondrial specific DNA polymerase-

Zeng, Q., Luo, X., Tang, Y., Liu, W

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[DOI] [PMC free article] [PubMed] [Google Scholar] Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, Hlatky M, Hsia J, Hulley S, Herd A, Khan S, Newby LK, Waters D, Vittinghoff E, Wenger N

First described in 2015, MOTS-c is unusual because it is encoded by mitochondrial DNA rather than nuclear DNA