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Potential long-term effects could include joint pain and increased risk of diabetes due to altered glucose metabolism

Gonadotrophins inhibit the expression of insulinlike growth factor binding proteinrelated protein2 mRNA in cultured human granulosaluteal cells

doi: 10.1007/s00464-009-0652-7

The potential elevation of intracellular calcium levels and PKC activation may lead to the apparent exocytosis of growth hormone-containing vesicles from pituitary cells