Johns Wort IM: Imatinib CPT-11: Irinotecan DTX: Docetaxel UGTs: UDP-glucuronosyltransferases SOF: Sorafenib OATPs: Organic anion transporting polypeptides OATs: Organic anion transporters OCTs: Organic cation transporters CDDP: Cisplatin MTX: Methotrexate ROS: Reactive oxygen species P-gp: P-glycoprotein BCRP: Breast cancer resistance protein MRPs: Multidrug resistance proteins BBB: Blood-brain barrier PTX: Paclitaxel DOX: Doxorubicin VCR: Vincristine 5-FU: 5-Fluorouracil CTX: Cyclophosphamide Ara-C: Cytarabine GFT: Gefitinib EGCG: ()-Epigallocatechin gallate BZM: Bortezomib EMT: Epithelial-mesenchymal transition PCD: Programmed cell death TNBC: Triple-negative breast cancer HCC: Hepatocellular carcinoma FA: Fanconi anemia pathway NSCLC: Non-small cell lung cancer CSCs: Cancer stem cells GC: Gastric carcinoma AKI: Acute kidney injury NS: Nephrotic syndrome CIPN: Chemotherapy-induced peripheral neurotoxicity OXA: Oxaliplatin GJG: Goshajinkigan CTX: Cyclophosphamide TPT: Topotecan MMC: Mitomycin C TMZ: Temozolomide MS: Modelling and simulation DDIs: Drugdrug interactions PBPK: Physiologically based pharmacokinetic RI: Reversible inhibition TDI: Time-dependent inhibition CsA: Cyclosporin A IT: Information technologies CMSS: Chi Mei search system CWMIN: Chinese-Western Medicine Integrative Information Network DHIQW: Drug Herb Interaction Query Website AI: Artificial intelligence ML: Machine learning NLP: Natural language processing ORR: Objective response rate DCR: Disease control rate QOL: Quality of life References Rashrash M, Schommer JC, Brown LM
184 In gastric cancer, serum factors IL-6 and IL-8 can stimulate CD45 + CD33 low CD11b dim MDSCs to express ARG1 and ultimately inhibit CD8 + T cell function through the PI3K-AKT signaling pathway (Fig
Investigating Effect of GSH on dsDNA by Fluorometry A total of 200 ng/ l dsDNA was incubated for 24 h at 37C, 100 rpm, in either presence or absence of 1 mM GSH at intrinsic pH and in 1 mM GSH at neutral pH (7.2)
It features complex injury mechanisms, dynamic pathological evolution, heterogeneous clinical manifestations, and high long-term disability rates
Similarly, for cyclosporine-induced hepatotoxicity, compounds such as wheat germ oil (Akool el 2015), avocado seeds (El-Magd et al
