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It is intriguing that 4-HNE, as a signaling molecule, can regulate the expression of many transcription factors while enhancing the antioxidant mechanism of cells

Brain Topogr 26:648660

Numerous studies have underscored the protective effects of Nrf2/HO-1 upregulation against oxidative stress (25-27), inextricably linking this pathway with ferroptosis regulation (28-30)

Rezaie, J., Feghhi, M

In atherogenesis, enhanced glycolysis further increases lactate production and release [46], which leads to extracellular acidification, increases EC permeability, and accelerates atherosclerosis progression [47]