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BH4 treatment did increase SAM but the difference was only borderline statistically significant [ F (1, 26) = 3.03, p = 0.09

J Biol Chem (2009) 284:350412

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Integration of Gene Replacement with Multimodality Cancer Treatment

Reduced consumption of NADPH has been observed when fatty acid synthesis is inhibited by AMP-activated protein kinase (AMPK) via inhibition of acetyl-coenzyme A carboxylase (55)