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While only a small fraction of -syn (~4%) is phosphorylated in healthy brains, substantial accumulation of pS129 (~90%) is observed in brains with Lewy pathology, implicating a potentially important association between this posttranslational modification and the accumulation of -syn aggregates concomitant with LB formation and neurodegeneration (Fujiwara et al., 2002

Nsairat H, Mahmoud IS, Odeh F, Abuarqoub D, Al-Azzawi H, Zaza R, et al

10.1038/s41392-020-0168-0 75 LeidnerR.Sanjuan SilvaN.HuangH.SprottD.ZhengC.ShihY

[28] Mutations in human telomerase genes are also associated with familial pulmonary fibrosis and in some patients with sporadic IPF (e.g

Guo J, et al