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Independently, it was described that tryptophan and KYN levels are increased in the CSF from ALS patients as compared to controls (Chen et al., 2010)

Effect of cysteine desulfhydrase gene disruption on l-cysteine overproduction in Escherichia coli

Results at the phylum level included increases in the relative abundance of Verrucomicrobia , Actinobacteria and Firmicutes and decreases in Proteobacteria and Bacteroidetes