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Cu (Copper): Copper is a metal element with many biological functions

Modest and variable effect sizes in animal models

One crucial signaling pathway activated by PRRs is the canonical NF-B pathway, which plays a significant role in the induction of pro-inflammatory cytokines, chemokines, and other inflammatory mediators in various innate immune cell types

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Therefore, more comparative studies examining the wound healing effects of GHK and larger peptides are needed to provide robust evidence on how peptide size and structural complexity influence therapeutic efficacy