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Molecular Probes, Eugene, OR, USA) and Cy3-conjugated sheep anti-rabbit antibodies (1:100

b , c , Quantification of extracellular and intracellular ROS levels in WT and XKR8 KO neutrophils treated with PMA (100 nM), measured using isoluminol ( b ) and DHR123 assay ( c ), respectively ( n = 3)

The precise mechanism underlying ferroptosis is still unknown, but it is known that altered iron metabolism, glutathione (GSH) depletion, GPX4 inactivation, and increased PUFA peroxidation by ROS play key roles in its onset and progression [80, 81]

YBX1 and MATR3 synergistically stabilize CCNL2 mRNA through m5C modification, enhancing its expression and promoting ovarian cancer cell proliferation and cisplatin resistance

R., Gooderham, N