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109,170 However, the side effects associated with targeting - and -secretases arise because these enzymes have a wide range of substrates that are vital in other physiological processes

In the glucose-alanine cycle, this reduction does not occur

Glutathione synthesis starts with the reaction between cysteine and glutamate to form -glutamyl-cysteine

Additive, proportional, or mixed error models were tested to describe residual variability

Microglial ferroptosis has been shown to amplify neurotoxicity by releasing pro-inflammatory mediators (such as TNF- and IL-1), and ferroptosis-related genes including ACSL4 and ALOX15 are highly enriched in microglia within PVL lesions