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Notably, AHE modeling significantly upregulated the pro-inflammatory factors IL-6 and TNF- in the rat cortex, while down-regulating the anti-inflammatory factor IL-10

FACS data were analyzed by FlowJo software

The efficacy of cysteine precursors N -acetylcysteine (NAC), S -Adenosyl- L -methionine (AdoMet), and L -2-oxothiazolidine-4-carboxylate (OTC) supplementation on GSH levels are evaluated in the next sections