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Extensive research has been carried out on novel nutritional supplements power to mitigate CC impact, while the mechanisms through which some nutrients or bioactive compounds exert beneficial effects on muscle mass are still not totally clear

J Transl Med 19:111 Malaguarnera M, Gargante MP, Cristaldi E et al (2008) Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue

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[161] There was low- to moderate-strength evidence of no benefit for most of the other medications used in RCTs, which included antidepressants (bupropion, mirtazapine, sertraline), antipsychotics (aripiprazole), anticonvulsants (topiramate, baclofen, gabapentin), naltrexone, varenicline, citicoline, ondansetron, prometa, riluzole, atomoxetine, dextroamphetamine, and modafinil