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Blocking NUPR1-dependent LCN2 expression significantly increased intracellular iron concentration and subsequent oxidative damage, including lipid peroxidation and DNA damage [87]

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Cells expressing LaccID were prepared as described above

NLRP3 inflammasome Inflammasomes are the complexes of multimeric cytosolic proteins and assemble in response to damage-associated molecular patterns and PAMPs, representing the inflammatory responses

In the treatment of heart failure, Kanlijian can increase left ventricular ejection fraction (LVEF), Shemnai injection can improve the average movement velocity of the mitral ring, and Qili qiangxin can reduce brain natriuretic peptide (BNP) levels, indicating its positive impact on cardiac function