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With the exception of heterogeneity in the causal relationship between erythritol and small intestinal Crohns disease (however, both the IVW method and the WM method results support a significant causal relationship), no evidence of heterogeneity or pleiotropy was found for the above significant results (as shown in Table 2 )

By consensus, this EAU Guidelines Panel have agreed to maintain the recommendations of the 3 rd Princeton Consensus Panel for the prescription of PDE5Is to patients with CVD or high CV risk [338-340]

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