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Detection of neonatal carnitine palmitoyltransferase II deficiency by expanded newborn screening with tandem mass spectrometry

Zhang, V.X., Sze, K.M-F., Chan, L-K., Ho, D.W-H., Tsui, Y-M., Chiu, Y-T., Husain, A., Huang, H., Tian, L., Wong, C.C-L., Ng, I.O-L

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Fertility Chronic toxicity studies in juvenile and adult rats and dogs demonstrated reduced spermatogenesis and testicular atrophy at oral doses of 400 mg/kg/day or greater in rats (approximately equivalent to or greater than the maximum human daily dose (MHD) on a mg/m2 basis) and 150 mg/kg/day or greater in dogs (approximately 1.4 times the MHD or greater on a mg/m2 basis)

Dang et al