elevated glutathione as a therapeutic strategy in alzheimer's disease The Role of Metabolism Chronic Illness Development and Its Potential Use Novel Target Glutathione in Skin Aging and

Valencia E, Hardy G

In one comparative study, n-propyl gallate provided the most robust protection across multiple readouts of neuroprotection, outperforming gallic acid and other analogues (40)

A summary of some of the data is shown in Fig

To explore the potential molecular mechanisms underlying the regulation of GSH metabolism by mitophagy, Signaling Pathways Project predicted TFs associated with 4 up-regulated genes involved in GSH synthesis (Gclm, Gss, Gclc, and Slc7a11) in P3O compared to controls

GSH Quantification Glutathione and GSSG were measured in lysates from cells in 6-well plates as previously described ( ROS Quantification by Spin-Trapping and EPR Spectroscopy Cells (5 10 6 /0.1 ml) were stimulated for 2 h with LPS, then incubated with 50 mM 5-tert-butoxycarbonyl-5-methyl-1-pyrroline-N-oxide (BMPO), synthetized as described previously ( Cell Viability Assay Cells were seeded in 96-well plates at 25,000/well in complete medium