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doi: 10.1001/JAMACARDIO.2021.3079 154

The PI3K/akt-nrf2 signaling pathway and mitophagy synergistically mediate hydroxytyrosol to alleviate intestinal oxidative damage

Our cells need energy to function at high efficiency, but as we age, decreasing oxygen levels tell our cells that their function is decreasing

None of the patients carried homozygous missense variants

Beacuse of its importance as a source of NADPH for fatty acid synthesis, you would expect to find a high activity of the pathway in tissues that synthesise fatty acids: liver, adipose tissue and lactating mammary gland