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Cyclosporin A (CsA) binds to cyclophilin D in mitochondria, targets MPTP and inhibits its excessive opening, thereby attenuating apoptosis and mitochondrial damage, and it has shown promising efficacy in in vivo experiments (animal models) (Chen et al., 2021a)

Hypoxia stress induces tissue damage, immune defense, and oxygen transport change in gill of silver carp ( Hypophthalmichthys molitrix ): evaluation on hypoxia by using transcriptomics

Animals The GCLM knockout (KO) mouse line (characterized previously 16 ) has been backcrossed into the C57BL/6J background for more than 10 generations

GSH is of paramount importance for the appropriate function of the immune system in general and particularly lymphocytes since low GSH levels inhibit T lymphocytes proliferation and subsequently disturbs the immune response (Hamilos et al., 1989